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When installing the Security Agent during server installation, Trend Micro Apex One needs access to all files that the agent scans. Since Microsoft Exchange Server queues messages in local directories, it is necessary to exclude these directories from scanning which allows the Exchange Server to process email messages.
Trend Micro Apex One automatically excludes all Microsoft Exchange 2000/2003 directories from scanning. Configure this setting on the web console (AgentsGlobal Agent Settings > Scan Settings on the Security Settings tab). For Microsoft Exchange 2007 scan exclusion details, refer to: